James C. Sacchettini received his undergraduate degree from St. Louis University in 1980 and his Ph.D. in Molecular Biology (Biochemistry) from Washington University School of Medicine (1984 – 1987). After postdoctoral studies at Washington University he joined the faculty of the Department of Biochemistry at Albert Einstein College of Medicine in 1990. Dr. Sacchettini moved to Texas A&M University in 1996 as a Professor in the Department of Biochemistry and Biophysics with a joint appointment in the Department of Chemistry. He is also the Wolfe-Welch Chair in Sciences at Texas A&M University, the Director of the Center for Structural Biology, the director of the TB Structural Genomics Group and a member of the faculty of the Institute of Biosciences and Technology in Houston, TX.
Professor Sacchettini’s research has primarily focused on the structure-based design and synthesis of novel compounds which are being tested as drug candidates against tuberculosis and malaria. Tuberculosis and malaria are the two most deadly infectious diseases. The Sacchettini lab uses protein crystallography to visualize proteins at their atomic resolution and computer programs to make designer inhibitors. The lab is also applying these techniques to Cancer and Alzheimer’s disease.